Bayesian Continual Reassessment Method Designs for Phase I Dose-Finding Trials

Bayesian Continual Reassessment Method Designs for Phase I Dose-Finding Trials

This GUI references the bcrm package and was built using Shiny.

Authors: Graham Seacat, Alex Karanevich, Byron Gajewski, Jo Wick, Huizhong Cui

Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number 1 P30 CA168524 (Principal Investigator: Dr. Roy Jensen). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

View the Tutorial

In order to upload a file, you must agree to the following: 'I aggree to use this software only for its intended purpose. I accept that I am using this software at my own risk. The authors, NINR, and NIH are not responsible for uses of this software.'

Decline Agree

Enter the dose levels (seperated by commas)

Enter the prior probabilities of toxicity corresponding to dose (seperated by commas)

Functional Form of Posterior Distribution

Hyperbolic Tangent (1-Parameter)

Logistic (1-Parameter)

Power (1-Parameter) *SUGGESTED*

Logisitc (2-Parameter)

Choose a Prior Distribution

Gamma *SUGGESTED* with parameter (1,1)

Uniform

Lognormal

Bivariate Lognormal

Enter value for first parameter:

Enter value for second parameter:

Choose the Target Toxicity Rate